Key result
The presence of both human chromosomes 2 and 5 in mouse-human cell hybrids was necessary for human interferon production, indicating at least two asyntenic gene loci are required.
Population
40 mouse-human cell hybrids
Design
Preclinical
Authors
Loading...
Offers no immediate clinical guidance in cardiovascular care; leaves open relevance of these loci to human disease.
The study demonstrates that at least two asyntenic gene loci on chromosomes 2 and 5 are necessary for the expression of human interferon.
Tan et al. (1974) studied this question. poly(I).poly(C) and Newcastle disease virus was evaluated on Human interferon production and chromosomal segregation. The presence of both human chromosomes 2 and 5 in mouse-human cell hybrids was necessary for human interferon production, indicating at least two asyntenic gene loci are required.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: