Key result
The presence of human chromosome 21 alone in human/mouse somatic cell hybrids was sufficient to confer sensitivity to human leukocyte and fibroblast interferons.
Why the study?
Is the presence of human chromosome 21 alone sufficient for hybrid cell sensitivity to human interferon?
Is the presence of human chromosome 21 alone sufficient for hybrid cell sensitivity to human interferon?
The presence of human chromosome 21 alone in human/mouse somatic cell hybrids is sufficient to confer sensitivity to human interferon.
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Hypothesis-generating in hybrid models; leaves open whether chromosome 21 confers interferon sensitivity in human disease.
Slate et al. (1978) studied this question. Human chromosome 21 was evaluated on Sensitivity to human leukocyte and fibroblast interferons. The presence of human chromosome 21 alone in human/mouse somatic cell hybrids was sufficient to confer sensitivity to human leukocyte and fibroblast interferons.
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