Population
Human-mouse hybrid cell lines with partial human chromosome complements
Comparison
Infection with poliovirus vs Resistant sublines (progeny of surviving cells)
Design
Preclinical
Authors
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Hypothesis-generating for viral receptor mapping; leaves open confirmation in human genomes and functional studies.
The study suggests that the human chromosome bearing the polio receptor gene is an acrocentric chromosome based on human-mouse hybrid cell line analysis.
Kusano et al. (1970) studied this question.
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