Population
Human-mouse somatic hybrid cell lines containing 3 to 12 human biarmed chromosomes
Comparison
Infection with poliovirus type 1 or viral… vs Human parental cells
Design
Preclinical
Authors
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Chromosome loss drives poliovirus resistance in hybrids; leaves open receptor gene identification for broader host-virus studies.
Demonstrates that human-mouse hybrid cells become resistant to poliovirus through the loss of the human chromosome responsible for the viral receptor.
Wang et al. (1970) studied this question.
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