Key result
Human-mouse hybrid cells preferentially eliminate human chromosomes, enabling chromosomal mapping of specific human genes.
Why the study?
Human-mouse hybrid cell lines that preferentially eliminate human chromosomes during growth can be used to determine the chromosomal location of specific human genes.
Key points are not available for this paper at this time.
Population
Mixed populations of mammalian somatic cells including human-mouse hybrids
Design
Experimental study using human-mouse hybrid cell lines
Answers are grounded in this paper and cite their sources.
May advance gene mapping tools; leaves open applications in cardiovascular genomics.
In cultures containing mixed populations of mammalian somatic cells, two cells of diverse origin may fuse and produce mono-nucleated hybrid descendants that can be grown indefinitely. Even cells of different species can be hybridized in this way. The nature of the human-mouse hybrid cell lines that Mary Weiss and I prepared in 19671 suggested that these hybrids could be used to determine in which chromosome a particular human gene is located. The property that distinguished the human-mouse lines from other interspecies hybrids made earlier in the laboratory of Ephrussi2 was that during growth, they eliminated human chromosomes preferentially. Since conditions . . .
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Howard Green (1974) studied this question. Human-mouse hybrid cell lines preferentially eliminated human chromosomes during growth, enabling their use to determine the chromosomal location of specific human genes.
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