January 1, 1983Nucleic Acids ResearchOpen Access

The 5' -flanking sequence of human interferon-β₁, gene is responsible for viral induction of transcription

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Structured PICO

Population

Mouse FM3A cells (strain FStk-/Oua-1)

Intervention

Transfection with a fusion gene (human IFN-beta 1 5'-flanking sequence linked to HSV thymidine kinase gene) and exposure to Newcastle disease virus (NDV)

Comparator

Mock-induced cells (no NDV exposure)

Outcome

Production of Tk specific transcript (15S transcript)surrogate

The 5'-flanking sequence of the human interferon-beta 1 gene contains specific DNA sequences required for virus-mediated activation of transcription.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not alter clinical care; extends mapping of virus-responsive elements in the human IFN-beta promoter.

Cite This Study

Ohno et al. (1983) studied this question.

synapsesocial.com/papers/6a6fbc2378a11c550e097c0c https://doi.org/10.1093/nar/11.16.5403

View Full Paper

Ask AI

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The 5' -flanking sequence of human interferon-β₁, gene is responsible for viral induction of transcription

Structured PICO

Discussion

Implication

Cite This Study

The 5' -flanking sequence of human interferon-β₁, gene is responsible for viral induction of transcription

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider