Key result
Exaggerated peak exercise SBP does not predict future resting hypertension in healthy premenopausal women.
Why the study?
Does an exaggerated peak exercise systolic blood pressure predict future resting hypertension and altered cardiometabolic risk factors in healthy normotensive premenopausal women?
Cohort (n=95)
Yes
Does an exaggerated peak exercise systolic blood pressure predict future resting hypertension and altered cardiometabolic risk factors in healthy normotensive premenopausal women?
Odds Ratio: 2.96 (95% CI 0.48–18.12)
Absolute Event Rate: 14% vs 5.8%
p-value: p=0.24
In healthy, active premenopausal women, an exaggerated peak exercise systolic blood pressure is not predictive of future resting hypertension over a 5-year follow-up.
Exaggerated exercise BP should not inform hypertension risk assessment in healthy premenopausal women; leaves open its prognostic value in other groups.
Objective: To investigate if an exaggerated peak exercise systolic blood pressure (peak ESBP) is associated with alteration of cardiometabolic risk factors and predict future resting hypertension in middle aged women. Methods: Data analysis was performed in 95 healthy normotensive premeno-pausal women at baseline and 84 after 5-year follow-up (age, 49.9 ± 1.9 years; BMI, 23.3 ± 2.2 kg/m2; resting BP, 117/73 ± 11.8/7.6 mmHg). Blood pressure was measured at rest and during a progressive exercise test on treadmill. Women were divided into two groups according to their peak ESBP <190 mmHg vs. ≥190 mmHg. Other outcome measures were: cardiorespiratory fitness (VO2 peak), body composition, body fat distribution and fasting plasma lipids, glucose and insulin levels. Results: 15% and 27% of women presented an exaggerated peak ESBP response (≥190 mmHg) at baseline and year 5 respectively. Linear mixed model repeated measures analysis revealed higher values of fasting glucose, resting systolic and diastolic BP in women with an exaggerated peak ESBP (≥190 mmHg) compared to women with a peak ESBP (<190 mmHg). No significant difference was observed between the two groups for VO2 peak, body composition and body fat distribution indices and other cardiometabolic risk factors. Finally, baseline peak ESBP was not a significant risk factor for future resting hypertension (OR: 2.96, 95%CI [0.48 - 18.12]; P = 0.24). Conclusion: Our results, despite being non significant, are of great interest because in healthy and active premenopausal women, exaggerated peak ESBP is not predictive of future hypertension after 5-year follow-up throughout menopause transition.
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Abdulnour et al. (2016) conducted a cohort in Healthy normotensive premenopausal women (n=95). Exaggerated peak exercise systolic blood pressure (≥190 mmHg) vs. Normal peak exercise systolic blood pressure (<190 mmHg) was evaluated on Future resting hypertension at 5 years (OR 2.96, 95% CI 0.48 - 18.12, p=0.24). An exaggerated peak exercise systolic blood pressure (≥190 mmHg) was not a significant predictor of future resting hypertension after a 5-year follow-up in healthy premenopausal women (OR 2.96, p=0.24).
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