Key result
Discharge heart rate ≥75 bpm linked to ~56% higher MACCE risk vs <60 bpm in CAD.
Why the study?
The optimal heart rate and optimal dose of beta-blockers in patients with coronary artery disease remained unclear.
Does higher discharge heart rate or low-dose β-blocker administration increase the risk of MACCE in patients with coronary artery disease?
Cohort (n=8,744)
Yes
Does higher discharge heart rate or low-dose β-blocker administration increase the risk of MACCE in patients with coronary artery disease?
Hazard Ratio: 1.56 (95% CI 1.25–1.93)
p-value: p=<0.001
A discharge heart rate of ≥75 beats/min is associated with worse clinical outcomes in patients with both acute and chronic coronary syndromes, and low-dose β-blocker therapy may be associated with worse outcomes in ACS.
May aid post-discharge risk stratification in CAD; leaves open whether rate reduction improves outcomes.
No takes yet. Share an insight, caveat, or question.
Oba et al. (2022) conducted a cohort in Coronary artery disease (CAD) (n=8,744). Heart rate ≥75 beats/min vs. Heart rate <60 beats/min was evaluated on Major adverse cardiac and cerebral events (MACCE) (HR 1.56, 95% CI 1.25-1.93, p=<0.001). A discharge heart rate of ≥75 beats/min was associated with a 56% increased risk of major adverse cardiac and cerebral events compared to <60 beats/min in patients with coronary artery disease (HR 1.56).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: