Key result
Noradrenaline and acetylcholine contract human epicardial veins while alpha CGRP, substance P, and VIP relax them.
This study demonstrates the perivascular innervation of human coronary veins and their vasomotor responses to various transmitters, suggesting a role in regulating coronary venous circulation.
No takes yet. Share an insight, caveat, or question.
Does not support clinical translation yet; leaves open the in vivo role of perivascular transmitters in human coronary venous tone.
Opgaard et al. (1995) studied this question. Classical and putative transmitters (noradrenaline, acetylcholine, neuropeptides) was evaluated on Innervation and vasomotor responses. Noradrenaline and acetylcholine induced powerful contractions in isolated human epicardial coronary veins, while alpha CGRP, substance P, and VIP induced potent relaxation in precontracted segments.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: