Key result
Higher peri-coronary adipose tissue attenuation linked to ~107% higher CAD odds in symptomatic young adults.
Why the study?
Peri-coronary adipose tissue attenuation is linked to coronary artery disease, but data on its role in young individuals are limited.
Is peri-coronary adipose tissue attenuation (PCAT) associated with coronary artery disease (CAD) in symptomatic young adults?
Cross-Sectional (n=733)
No
Is peri-coronary adipose tissue attenuation (PCAT) associated with coronary artery disease (CAD) in symptomatic young adults?
Coronary inflammation measured by PCAT on CCTA is associated with CAD in symptomatic young adults, even those with a zero calcium score, suggesting its utility as an early risk marker.
Answers are grounded in this paper and cite their sources.
May support PCAT as early CAD marker in symptomatic young adults; leaves open prospective validation before clinical adoption.
Background: Peri-coronary adipose tissue attenuation (PCAT), a marker of coronary inflammation, is linked to coronary artery disease (CAD), but data on the role of PCAT in young individuals are limited. Aims: This study explores the interplay of PCAT and CAD by CCTA, in a symptomatic young cohort. Methods and Conclusion: Coronary inflammation is associated with CAD in young patients, independently of traditional risk factors, even among patients with CAC=0 score. These findings highlight its potential as an early marker for guiding preventive strategies.
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Filtz et al. (2025) conducted a cross-sectional in Suspected coronary artery disease (n=733). Higher peri-coronary adipose tissue attenuation (PCAT) vs. Lower PCAT was evaluated on Presence of coronary artery disease (any coronary plaque) (Adj-OR 2.07, 95% CI 1.30-3.57, p=0.009). Higher peri-coronary adipose tissue attenuation was independently associated with the presence of coronary artery disease in symptomatic young adults.
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