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Reaction of 1,4,7,10-tetra-azacyclododecane (cyclen) with 1,2-dibromoethane connects an adjacent pair of secondary amino groups, by means of an ethano bridge, reinforcing the macrocycle and allowing it to circumscribe rigidly nickel(II); an ion to which it would normally be bound in a folded conformation.
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Ramasubbu et al. (1982) studied this question.
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