Association of Severity Serum Iron Indices and High-sensitivity C-reactive Protein with Disease Severity in Men with Alcoholic Liver Disease

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Aim and objective: Earlier studies have reported an association between chronic alcohol consumption, iron overload and liver disease.However, there are only limited data from India on serum iron indices and inflammatory markers in alcoholic liver disease.The objective of the study is to estimate serum iron indices and C-reactive protein levels in alcoholic liver disease and their association with disease severity. Materials and methods:We enrolled 46 alcoholic liver disease cases and 40 controls.Serum iron, ferritin and high-sensitivity C-reactive protein levels were estimated in both groups.Results: Serum iron, ferritin, transferrin saturation and C-reactive protein were significantly increased in alcoholic liver disease patients compared to controls.Both iron (r = 0.372, p = 0.011) and ferritin (r = 0.352, p = 0.016) were positively correlated with model for end stage liver disease score an indicator of severity in alcoholic liver disease.C-reactive protein had a significant correlation with iron (r = 0.294, p = 0.048), ferritin (r = 0.483, p = 0.001) and model for end stage liver disease score (r = 0.344, p = 0.019) in alcoholic liver disease cases.Conclusion: We conclude that serum iron indices and C-reactive protein are elevated in alcohol liver disease and associated with severity of liver disease.Clinical significance: Serum iron indices and C-reactive protein can be used as biomarkers for predicting disease severity in alcoholic liver disease.