Key result
Prolonged DAPT is linked to fewer MACCEs in non-anemic patients but only major bleeding in anemics.
Why the study?
The outcomes of prolonged dual antiplatelet therapy (DAPT) depending on baseline anemia after PCI remained to be evaluated.
Does prolonged dual antiplatelet therapy (>12 months) reduce MACCEs or increase bleeding in patients with baseline anemia after PCI?
Cohort (n=1,470)
Does prolonged dual antiplatelet therapy (>12 months) reduce MACCEs or increase bleeding in patients with baseline anemia after PCI?
p-value: p==0.001
Extended DAPT beyond 12 months after PCI increases major bleeding without reducing ischemic events in patients with baseline anemia, suggesting shorter DAPT may be preferable in this subgroup.
Supports caution with prolonged DAPT in anemic post-PCI patients; leaves open need for randomized confirmation of differential effects.
PURPOSE: We aimed to evaluate the outcomes of prolonged dual antiplatelet therapy (DAPT) depending on baseline anemia after percutaneous coronary intervention (PCI). MATERIALS AND METHODS: Among the 1470 study participants, 448 (30.5%) were classified as having baseline anemia. We categorized the study population according to baseline anemia and DAPT duration: ≤12-month (m) DAPT (n=226) vs. >12-m DAPT (n=222) in anemic patients, and ≤12-m DAPT (n=521) vs. >12-m DAPT (n=501) in non-anemic patients. RESULTS: =0.001) among anemic patients. CONCLUSION: Although extended DAPT led to a reduction in MACCEs in non-anemic patients, it was related to increased major bleeding without reducing MACCEs in anemic patients.
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Kim et al. (2022) conducted a cohort in Percutaneous coronary intervention (n=1,470). Prolonged dual antiplatelet therapy (>12 months) vs. ≤12-month dual antiplatelet therapy was evaluated on Major adverse cardiac and cerebrovascular events (MACCEs) and major bleeding (p==0.001). Prolonged dual antiplatelet therapy (>12 months) reduced MACCEs in non-anemic patients but increased major bleeding without reducing MACCEs in anemic patients.
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