Key result
Novel insulin sensitizers like troglitazone promise new treatments for PCOS fertility and long-term disease prevention.
Why the study?
Do insulin sensitizers like troglitazone improve fertility and prevent long-term metabolic disease in patients with polycystic ovarian syndrome?
Do insulin sensitizers like troglitazone improve fertility and prevent long-term metabolic disease in patients with polycystic ovarian syndrome?
Answers are grounded in this paper and cite their sources.
Insulin sensitizers such as troglitazone represent a promising therapeutic approach for addressing both the reproductive and metabolic complications of polycystic ovarian syndrome.
The aetiology of the polycystic ovarian syndrome together with new advances in the molecular genetics and possible candidate genes for the inheritance of the syndrome is discussed. The possible role of leptin in the obesity of polycystic ovarian syndrome is reviewed. Hyperinsulinaemia acts not only as the trigger for hyperandrogenaemia and infertility, but also by stimulating plasminogen activator inhibitor type 1; hyperinsulinaemia may also promote atherogenesis in polycystic ovarian syndrome. The long-term effects of the metabolic derangements accompanying hyperinsulinaemia are reviewed. Special emphasis is placed on the use of novel insulin sensitizers such as troglitazone which promise new treatment opportunities in polycystic ovarian syndrome for both fertility and long-term disease prevention.
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Rina M. Davison (1998) conducted a review in Polycystic ovarian syndrome. Insulin sensitizers (e.g., troglitazone) was evaluated. Novel insulin sensitizers such as troglitazone promise new treatment opportunities in polycystic ovarian syndrome for both fertility and long-term disease prevention.
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