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June 1, 1998Current Opinion in Obstetrics & Gynecology

New approaches to insulin resistance in polycystic ovarian syndrome

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Key result

Novel insulin sensitizers like troglitazone promise new treatments for PCOS fertility and long-term disease prevention.

Why the study?

Do insulin sensitizers like troglitazone improve fertility and prevent long-term metabolic disease in patients with polycystic ovarian syndrome?

Population

Patients with polycystic ovarian syndrome (PCOS)

Design

Review

Authors

RDRina M. Davison

Discussion

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Overview

May support dual fertility-metabolic benefits in PCOS; leaves open confirmation in prospective trials before practice change.

Structured PICO

Do insulin sensitizers like troglitazone improve fertility and prevent long-term metabolic disease in patients with polycystic ovarian syndrome?

P
Population
Patients with polycystic ovarian syndrome (PCOS)
I
Intervention
Insulin sensitizers (e.g., troglitazone)

Insulin sensitizers such as troglitazone represent a promising therapeutic approach for addressing both the reproductive and metabolic complications of polycystic ovarian syndrome.

Cite This Study

Rina M. Davison (1998) conducted a review in Polycystic ovarian syndrome. Insulin sensitizers (e.g., troglitazone) was evaluated. Novel insulin sensitizers such as troglitazone promise new treatment opportunities in polycystic ovarian syndrome for both fertility and long-term disease prevention.

synapsesocial.com/papers/6aa72f0fd6f8ed579c00a4a9https://doi.org/10.1097/00001703-199806000-00003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome.1996 · 428 citations
  2. 2Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndrome<sup>1</sup>1997 · 452 citations
  3. 3Genetics: The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome1994 · 71 citations
  4. 4Association of the Steroid Synthesis Gene Cyp11a with Polycystic Ovary Syndrome and Hyperandrogenism1997 · 294 citations
  5. 5Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome1992 · 429 citations