Key result
A single trazodone dose induces complete heart block in patients with underlying conduction risk.
Trazodone may cause severe cardiac conduction issues, such as complete heart block, in susceptible individuals.
May warrant caution with trazodone in patients at conduction risk; leaves open need for prospective safety data.
Forty minutes after receiving a single starting dose of trazodone, a patient developed complete heart block. The case illustrates that, despite the results of earlier studies, trazodone's effect on cardiac conduction may be severe in individuals at risk for conduction delay.
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Rausch et al. (1984) studied this question. A single starting dose of trazodone induced complete heart block, demonstrating that its effect on cardiac conduction can be severe in individuals at risk for conduction delay.
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