Key result
Predominant AS linked to ~11% lower 10-year survival versus AR after the Bentall procedure.
Why the study?
Aortic stenosis in patients undergoing the Bentall procedure for aortic root aneurysm represents a distinct clinical entity with more comorbidities, but whether predominant aortic valve pathology influences post-Bentall outcomes remains unclear.
Does predominant aortic stenosis compared to aortic regurgitation worsen outcomes in patients undergoing the Bentall procedure for aortic root aneurysm?
Cohort (n=442)
No
Does predominant aortic stenosis compared to aortic regurgitation worsen outcomes in patients undergoing the Bentall procedure for aortic root aneurysm?
Absolute Event Rate: 76% vs 87%
p-value: p=<0.001
While long-term survival is lower in patients with aortic stenosis undergoing the Bentall procedure compared to those with aortic regurgitation, this difference is likely driven by baseline comorbidities rather than the valve pathology itself.
Survival difference after Bentall may reflect comorbidities rather than valve lesion; leaves open independent prognostic role of aortic stenosis.
Objectives Aortic stenosis (AS) in patients undergoing the Bentall procedure for aortic root aneurysm is less frequent than aortic regurgitation (AR) and represents a distinct clinical entity with a higher prevalence of comorbidities, including coronary artery disease. This study examined whether the predominant aortic valve pathology influences outcomes after the Bentall procedure. Methods From 2015 to 2025, 442 patients who underwent elective Bentall procedures were retrospectively reviewed after predefined exclusions. Patients were stratified according to predominant aortic valve pathology into an AS group ( n = 90) and an AR group ( n = 352). Perioperative outcomes, early and late complications, freedom from reoperation, and long‐term survival were evaluated. Results Patients in the AS group were older than those in the AR group and had a higher proportion of female patients, resulting in a higher EuroSCORE II, while other baseline characteristics were comparable. The incidence of major perioperative complications was comparable between groups, and overall 30‐day mortality was 3%, with no significant difference between the AS and AR groups (5.4% vs. 2.5%, p = 0.26). During a mean follow‐up of 53 months (1858 patient‐years), overall survival was significantly lower in the AS group compared with the AR group (10 year survival: 76% vs. 87%, p < 0.001). Freedom from reoperation and long‐term complications, including stroke and endocarditis, were similar between groups. Conclusions Patient comorbidities, perioperative complications, and surgery‐related technical factors, rather than the type of aortic valve disease, are the main determinants of outcomes after Bentall procedures.
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Kutay et al. (2026) conducted a cohort in Aortic valve stenosis and root aneurysm (n=442). Predominant aortic stenosis vs. Predominant aortic regurgitation was evaluated on 10-year overall survival (p=<0.001). In patients undergoing the Bentall procedure, predominant aortic stenosis was associated with significantly lower 10-year overall survival compared to aortic regurgitation (76% vs. 87%, p<0.001).
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