Key result
Multimodality imaging and biopsy identify pleuropulmonary synovial sarcoma treated with neoadjuvant chemotherapy and surgery.
Why the study?
Pleuropulmonary synovial sarcomas are extremely rare, with only a few cases reported in the literature.
Case Report (n=1)
This case report highlights the rare presentation of pleuropulmonary synovial sarcoma of the chest wall in a 39-year-old male, managed with neoadjuvant chemotherapy and surgery.
Rare case supports multimodality diagnosis and neoadjuvant management; leaves open standardized protocols for this entity.
Pleuropulmonary synovial sarcoma is a subtype of synovial sarcomas that commonly arises from the chest wall, pleura, lungs and the heart. They are extremely rare, with only a few cases reported in the literature. It usually affects young and middle-aged adults with no gender predilection. Chest radiographs usually show a pleural-based mass, parenchymal consolidation, or a near complete opacification of the hemithorax. On contrast-enhanced CT, synovial sarcomas of the chest wall typically appear as a well-defined, heterogeneously enhancing mass with bone destruction and infiltration of chest wall musculature. MRI usually demonstrates a heterogeneous mass with areas of both high and low T1 signal intensities representing areas of hemorrhage and necrosis. We report a case of a 39- year old African male patient who presented to our hospital complaining of chest pain of 4 months duration. The plain chest radiograph showed complete opacification of the left hemithorax. Contrast-enhanced CT and MRI were then performed revealing a large left-sided heterogeneous mass. PET-CT demonstrated avid FDG uptake in the solid components of the mass with no evidence of distant metastasis.. An ultrasound-guided biopsy was performed, and histopathology revealed a locally advanced primary synovial sarcoma of the chest wall. Treatment consisted of neoadjuvant chemotherapy followed by surgical resection.
No takes yet. Share an insight, caveat, or question.
Abdulghaffar et al. (2020) conducted a case report in Pleuropulmonary synovial sarcoma of the chest wall (n=1). Neoadjuvant chemotherapy followed by surgical resection was evaluated. A 39-year-old male with pleuropulmonary synovial sarcoma of the chest wall was diagnosed using multimodality imaging and biopsy, and treated with neoadjuvant chemotherapy and surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: