Key result
Sublingual nifedipine increases liver blood flow ~33% vs control, whereas glyceryl trinitrate reduces it.
Why the study?
Does sublingual nifedipine or glyceryl trinitrate alter apparent liver blood flow in healthy volunteers?
RCT (n=6)
Random order crossover
No
Does sublingual nifedipine or glyceryl trinitrate alter apparent liver blood flow in healthy volunteers?
p-value: p=<0.05
Single doses of nifedipine and glyceryl trinitrate have opposing acute effects on apparent liver blood flow in healthy subjects.
Acute effects in healthy volunteers should not alter practice; leaves open impact on hepatic drug clearance in patients.
The effects of sublingual nifedipine (10 mg) and of glyceryl trinitrate (500 micrograms), which produce arterial and venous vasodilatation respectively, on indocyanine green estimated apparent liver blood flow (LBF) were studied in six healthy volunteers. Nifedipine significantly increased (33 +/- 12%; mean +/- s.e. mean) and glyceryl trinitrate significantly reduced (18 +/- 3%) LBF. There was a positive relationship (r = 0.92, P less than 0.05) between the reduction in mean arterial pressure produced by nifedipine and the percentage increase in LBF. These results show that single doses of nifedipine and glyceryl trinitrate significantly alter LBF.
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J. Feely (1984) conducted an RCT in Healthy volunteers (n=6). Nifedipine and Glyceryl trinitrate vs. Control (no drug) was evaluated on Apparent liver blood flow (LBF) (p=<0.05). Single sublingual doses of nifedipine significantly increased apparent liver blood flow by 33%, whereas glyceryl trinitrate significantly reduced it by 18% compared to control.
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