Key result
Novel hnRNP-R2 isoform exhibits neural-specific expression distinct from ubiquitous hnRNP-R1 during brain development.
Neural hnRNP-R2 expression warrants targeted functional studies; leaves open relevance to neurodevelopment or disease.
In the present study, we cloned a novel isoform of heterogeneous nuclear ribonucleoprotein-R (hnRNP-R), hnRNP-R2. Compared with the previously reported hnRNP-R (hnRNP-R1), it lacks the exon 5. Two proteins are both nuclear. The expression of hnRNP-R1 is not tissue-specific and is strikingly higher than that of hnRNR-R2. In comparison, the expression of hnRNP-R2 is low and neural-specific. The expression of two isoforms is differentially regulated during brain development. The results suggest that hnRNP-R may contribute to the regulation of neural development through the variation of hnRNP-R components in the hnRNP complex.
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Huang et al. (2005) studied this question. hnRNP-R2 vs. hnRNP-R1 was evaluated on Expression and localization of hnRNP-R isoforms. A novel isoform of hnRNP-R, hnRNP-R2, exhibits low, neural-specific expression that is differentially regulated during brain development compared to the ubiquitously expressed hnRNP-R1.
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