Key result
RS-1893 lowers BP and increases heart rate, cardiac output, and regional blood flow in rats.
Why the study?
Does intravenous RS-1893 affect central and peripheral hemodynamics in anesthetized rats?
Does intravenous RS-1893 affect central and peripheral hemodynamics in anesthetized rats?
RS-1893 acts as a systemic vasodilator in rats, particularly increasing renal and gastric blood flow while decreasing blood pressure and increasing cardiac output.
Answers are grounded in this paper and cite their sources.
RS-1893 shows vasodilatory effects in rat models; hypothesis-generating and should not change clinical practice.
After the use of two radionuclides in the tracer microspheres technique in the rat was verified, we examined the central and peripheral hemodynamic effects of RS-1893. an orally active cardiotonic agent. An intravenous infusion of RS-1893 at a dose of 3 μg/kg/min gradually decreased blood pressure and increased heart rate and cardiac output. Blood flows in the kidney and stomach were increased. There was no organ in which blood flow was decreased despite the fall in blood pressure. These data suggest that RS-1893 dilates blood vessels in the whole body, especially in the kidney and stomach
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MIYAKE et al. (1989) studied Anesthetized rats. RS-1893 was evaluated on Central and peripheral hemodynamics (blood pressure, heart rate, cardiac output, blood flows). Intravenous infusion of RS-1893 at 3 μg/kg/min decreased blood pressure, increased heart rate and cardiac output, and increased blood flow in the kidney and stomach in anesthetized rats.
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