Key result
Increasing age was independently associated with increasing carotid intima-media thickness (regression coefficient = 0.004; p = 0.004) in Indonesian subjects with multiple CVD risk factors.
Cross-Sectional
Yes
Effect estimate: regression coefficient 0.004
p-value: p=0.004
This study establishes normative CIMT data for Indonesian patients with multiple CVD risk factors not on lipid-lowering therapy, demonstrating a significant independent association between increasing CIMT and age.
Normative CIMT data now available for high-risk Indonesians; extends regional evidence but leaves open prognostic utility.
Carotid intima-media thickness (CIMT) is frequently utilized for detection of subclinical atherosclerosis. This study aims to investigate the association between the CIMT values and demographic characteristics, cardiovascular disease (CVD) risk factors, lipid biochemistry profiles, and high-sensitivity C-reactive protein (hs-CRP) levels among the Indonesian population. Subjects who had two or more CVD risk factors but were not receiving lipid-lowering therapy were recruited from six hospitals of Indonesia. Measurements of CIMT are obtained by ultrasonography of 12 sites within the common carotid artery. CVD risk factors, lipid and glucose profiles, and hs-CRP values were analyzed with respect to distribution of CIMT. The mean-max CIMT was 0.805 ± 0.190 mm (minimum, 0.268 mm; maximum, 1.652 mm) and the mean-mean CIMT was 0.614 ± 0.190 mm (minimum, 0.127 mm; maximum, 1.388 mm). Multivariate analyses confirmed an independent association between increasing CIMT and increasing age (regression coefficient = 0.004; p = 0.004). Our data show normative mean-mean CIMT data for Indonesian subjects with two or more CVD risk factors who are not receiving lipid-lowering therapy, which may guide CVD risk stratification of asymptomatic individuals in Indonesia.
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Kaligis et al. (2016) conducted a cross-sectional in Cardiovascular disease risk factors. Increasing age was evaluated on Carotid intima-media thickness (CIMT) (regression coefficient 0.004, p=0.004). Increasing age was independently associated with increasing carotid intima-media thickness (regression coefficient = 0.004; p = 0.004) in Indonesian subjects with multiple CVD risk factors.
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