Key result
Metabolic syndrome and diabetes are linked to substantially greater coronary plaque lipid index vs controls.
Why the study?
Do patients with metabolic syndrome or diabetes mellitus have different coronary plaque characteristics assessed by optical coherence tomography compared to controls?
Cross-Sectional (n=171)
Do patients with metabolic syndrome or diabetes mellitus have different coronary plaque characteristics assessed by optical coherence tomography compared to controls?
Absolute Event Rate: 1086% vs 796%
p-value: p=0.008
Patients with metabolic syndrome and diabetes mellitus have larger lipid cores in coronary plaques compared to controls, but metabolic syndrome criteria alone do not identify vulnerable plaque features like thin-cap fibroatheroma.
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Greater plaque lipid content on OCT in metabolic syndrome and diabetes is hypothesis-generating; leaves open prognostic value for events or intervention.
Yonetsu et al. (2013) conducted a cross-sectional in Metabolic syndrome and diabetes mellitus (n=171). Metabolic syndrome and diabetes mellitus vs. Control group without diabetes mellitus or metabolic syndrome was evaluated on Lipid index (LI) (p=0.008). Patients with metabolic syndrome and diabetes mellitus had significantly greater coronary plaque lipid index compared to controls (1086 and 1164 vs 796 mm; P=0.008 and P<0.001, respectively).
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