Key result
Rigid BP control with sodium nitroprusside during CEA links to 0% mortality and neurologic deficits.
Why the study?
Systolic hypertension after carotid endarterectomy is associated with increased mortality and neurologic deficit, but whether neurologic deficit is the cause or result of postoperative hypertension remained undetermined.
Does rigid control of blood pressure with sodium nitroprusside prevent mortality and neurologic deficits in symptomatic patients undergoing carotid endarterectomy?
Observational (n=41)
Does rigid control of blood pressure with sodium nitroprusside prevent mortality and neurologic deficits in symptomatic patients undergoing carotid endarterectomy?
Rigid perioperative blood pressure control with sodium nitroprusside may prevent mortality and neurologic deficits in patients undergoing carotid endarterectomy.
Caution against routine nitroprusside use from this series alone; leaves open whether rigid BP control reduces mortality or deficits after carotid endarterectomy.
Systolic hypertension after carotid endarterectomy is frequently a serious problem associated with increased mortality and increased incidence of neurologic deficit. While this association is well reported, the authors of most series have been unable to determine whether the neurologic deficit was the cause or result of postoperative hypertension. From October 1978 to August 1981, 41 consecutive symptomatic patients who had carotid endarterectomy were examined with regard to hypertension control. The incidence of preoperative hypertension was 59%. All hypertension was controlled preoperatively in the hospital. Postoperative incidence of hypertension was 64%. Rigid control of blood pressure during the operative procedure and postoperative period was obtained with sodium nitroprusside. There was no mortality and no patients in this group had neurologic deficits. Our conclusion is that while the success or failure of the carotid endarterectomy is known to be multifactorial, this small group of patients indicates the need for rigid control of blood pressure in improving overall results.
No takes yet. Share an insight, caveat, or question.
SKUDLARICK et al. (1982) conducted an observational in Carotid endarterectomy (n=41). Rigid control of blood pressure with sodium nitroprusside was evaluated on Mortality and neurologic deficits. Rigid control of blood pressure with sodium nitroprusside during and after carotid endarterectomy resulted in 0% mortality and 0% neurologic deficits in a series of 41 patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: