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September 14, 2026Neurology

Natural Course and Clinical Outcomes of Patients With Hemorrhagic Moyamoya Disease

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Authors

CCCheng ChenGGGan GaoHWHui Wang

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Overview

Retrospective study finds encephaloduroarteriosynangiosis reduces rebleeding in hemorrhagic moyamoya disease, suggesting indirect revascularization improves long-term outcomes.

Key Points

  • To evaluate the natural clinical course of hemorrhagic moyamoya disease and investigate the therapeutic efficacy of indirect revascularization.
  • Retrospectively analyzed patients with hemorrhagic moyamoya disease admitted to Chinese PLA General Hospital between April 2002 and March 2022.
  • Identified predictors of poor prognosis and rebleeding using logistic and Cox proportional hazards regression models.
  • Compared outcomes between conservative treatment and encephaloduroarteriosynangiosis (EDAS) after adjusting for confounding with overlap weighting.
  • In the natural history of the disease, anterior choroidal artery (AChA) dilation was significantly associated with recurrent hemorrhage.
  • Female sex, AChA dilation, and bilateral lesions independently predicted poor functional outcomes.
  • Encephaloduroarteriosynangiosis (EDAS) was associated with a significantly decreased incidence of rebleeding and superior clinical outcomes compared with conservative treatment (P < 0.001).

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b2e10926e14a848b172chttps://doi.org/10.1212/wnl.0000000000218493
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical features, treatment and long-term outcomes of hemorrhagic moyamoya disease in children: an extensive follow-up study2025
  2. 2EXPRESS: Encephaloduroarteriosynangiosis Effectively Reduces Rebleeding Risk in Adults with Hemorrhagic Moyamoya Disease: A Long-Term Ambidirectional Cohort Study2026
  3. 3Hemorrhage in Adult Moyamoya Disease With Intracranial Aneurysms: A Long-Term Observational Study on the Roles of Moyamoya Vessels and Admission Glasgow Coma Scales2026
  4. 4Pediatric Hemorrhagic Moyamoya Disease2026 · 2 citations
  5. 5The effectiveness of indirect revascularization on haemorrhagic moyamoya disease and the activities that trigger intracranial haemorrhage: a comprehensive study2026