Single-cell multi-omics landscape of mouse embryogenesis

Q: What does this research mean for the field?

A paired single-cell dual-omics atlas capturing joint transcriptome and chromatin-accessibility profiles across mouse embryogenesis stages E8.5-E12.5 provides a quantitative framework for understanding lineage specification, organogenesis timing, and the regulatory origins of congenital disease. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

邓秋婷(Qiuting Deng)

doi:10.26036/cnp0010182

September 12, 2026Open Access

Single-cell multi-omics landscape of mouse embryogenesis

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Key Points

Map paired single-cell transcriptomes and chromatin accessibility across developmental stages to establish a quantitative regulatory framework for mammalian embryogenesis.
Profiled mouse embryonic cells using high-throughput single-cell chromatin accessibility and transcriptome sequencing (HT-scCAT-seq).
Sampled embryonic tissues across five developmental stages ranging from embryonic day E8.5 to E12.5.
Generated a comprehensive, cell-type-resolved dual-omics atlas that captures joint gene expression and chromatin-accessibility states.
Established a quantitative framework defining the timing of organogenesis, mechanisms of lineage specification, and regulatory origins linked to congenital disease.

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Implication

Multi-omic profiling reveals joint transcriptome and chromatin dynamics in developing mouse embryos, highlighting regulatory mechanisms underlying organogenesis and congenital disease.

Abstract

we present a paired single-cell dual-omics atlas of mouse embryogenesis using HT-scCAT-seq, capturing joint transcriptome and chromatin-accessibility profiles across five stages (E8.5-E12.5), this cell-type-resolved resource establishes a quantitative framework for understanding lineage specification, organogenesis timing, and the regulatory origins of congenital disease.

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邓秋婷(Qiuting Deng) (2026) studied this question.

synapsesocial.com/papers/6aa7b31b0926e14a848b1ce7 https://doi.org/10.26036/cnp0010182

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Single-cell multi-omics landscape of mouse embryogenesis

Key Points

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Implication

Abstract

Discussion

Cite This Study

Single-cell multi-omics landscape of mouse embryogenesis

Key Points

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Implication

Abstract

Discussion

Cite This Study

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