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September 10, 2025Cell ReportsOpen Access

A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space

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Authors

LHLuke HarlandTLTim LohoffNKNoushin Koulena

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Overview

Spatial transcriptomics maps gene expression in mouse embryos, highlighting organogenesis and gastrulation.

Key Points

  • The atlas identifies over 150,000 mouse cells, revealing spatial logic in mesodermal fate decisions.
  • At embryonic days E7.25 and E7.5, gene expression dynamics were mapped across anterior-posterior and dorsal-ventral axes.
  • A computational pipeline integrates single-cell RNA-seq datasets, enhancing comparative analysis for developmental studies.
  • This resource serves as an interactive tool for stem cell and developmental biology research, enabling explorations of embryogenesis.

Cite This Study

Harland et al. (2025) studied this question.

synapsesocial.com/papers/68c19f7f54b1d3bfb60dab7dhttps://doi.org/10.1016/j.celrep.2025.116047
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Three-dimension transcriptomics maps of whole mouse embryo during organogenesis2024 · 6 citations
  2. 2Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation2026 · 3 citations
  3. 3Single-cell multi-omics landscape of mouse embryogenesis2026
  4. 4Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays2022 · 1,879 citations
  5. 5Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation2024 · 3 citations