What does this research mean for the field?

An iodoarene-catalyzed I(I)/I(III) catalytic cycle enables the unified aminohalogenation of alkenes at room temperature, with regioselectivity dictated by the interplay of steric and electronic effects. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Develop a unified, mild catalytic protocol for the aminohalogenation of diverse alkenes utilizing an I(I)/I(III) catalytic cycle.

September 14, 2026Organic Letters

Aminohalogenation of Alkenes Enabled by I(I)/I(III) Catalysis

View Full Paper

Ask AI

Bookmark

Authors

QYQuan Yin KDKong De-yi FGFan Gong

Discussion

Member takes

Overview

Laboratory study demonstrates catalytic aminohalogenation across diverse alkenes via an iodine cycle, highlighting divergent regioselectivity for chemical synthesis.

Key Points

Develop a unified, mild catalytic protocol for the aminohalogenation of diverse alkenes utilizing an I(I)/I(III) catalytic cycle.
Applied an iodoarene catalyst in the presence of inexpensive halogen sources to install chlorine, bromine, or iodine across diverse alkenes at room temperature.
Conducted mechanistic experiments to elucidate the underlying pathway and characterize the active reaction intermediates.
Achieved broad and unified room-temperature installation of Cl, Br, and I across both aryl- and alkyl-substituted alkenes.
Identified divergent regioselectivity governed by electronic and steric factors, providing Markovnikov products for aryl alkenes and sterically controlled attack for alkyl alkenes.
Established that the reaction proceeds via an electrophilic mechanism involving a reactive hypervalent imidoiodine intermediate.

Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3950926e14a848b29e0 https://doi.org/10.1021/acs.orglett.6c03347

View Full Paper

Ask AI

Bookmark

September 14, 2026Organic Letters

Aminohalogenation of Alkenes Enabled by I(I)/I(III) Catalysis

View Full Paper

Ask AI

Bookmark

Authors

QYQuan Yin KDKong De-yi FGFan Gong

Discussion

Member takes

Overview

Laboratory study demonstrates catalytic aminohalogenation across diverse alkenes via an iodine cycle, highlighting divergent regioselectivity for chemical synthesis.

Key Points

Develop a unified, mild catalytic protocol for the aminohalogenation of diverse alkenes utilizing an I(I)/I(III) catalytic cycle.
Applied an iodoarene catalyst in the presence of inexpensive halogen sources to install chlorine, bromine, or iodine across diverse alkenes at room temperature.
Conducted mechanistic experiments to elucidate the underlying pathway and characterize the active reaction intermediates.
Achieved broad and unified room-temperature installation of Cl, Br, and I across both aryl- and alkyl-substituted alkenes.
Identified divergent regioselectivity governed by electronic and steric factors, providing Markovnikov products for aryl alkenes and sterically controlled attack for alkyl alkenes.
Established that the reaction proceeds via an electrophilic mechanism involving a reactive hypervalent imidoiodine intermediate.

Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3950926e14a848b29e0 https://doi.org/10.1021/acs.orglett.6c03347

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark