Effect of self-activating phthalocyanine gel on palatal donor site healing, inflammatory biomarkers, somatosensory and patient-centered outcomes: a randomized split-mouth clinical trial
Randomized split-mouth trial demonstrates phthalocyanine gel reduces palatal remodeling area and elevates interleukin-10, suggesting enhanced local anti-inflammatory tissue repair.
Key Points
To evaluate the clinical, immunological, somatosensory, and patient-centered effects of a self-activating phthalocyanine gel on palatal wound healing after connective tissue graft harvesting.
Conducted a randomized, crossover, split-mouth clinical trial in 20 participants undergoing subepithelial connective tissue graft harvesting.
Donor sites received either topical self-activating phthalocyanine gel (PHYG) or placebo gel (CG).
Wound healing was tracked across 60 days, patient-reported outcomes over 14 days, inflammatory cytokines (IL-10) at days 3 and 7, and mechanical sensory thresholds up to 6 months.
Phthalocyanine gel demonstrated superior reduction in residual remodeling area relative to control, while wound epithelialization, tissue thickness, and patient-centered scores were similar between arms.
Interleukin-10 levels increased significantly in the phthalocyanine group at postoperative evaluations, indicating a more pronounced anti-inflammatory response.
Mechanical detection thresholds remained stable, whereas mechanical pain thresholds indicated transient hypersensitivity at 2 months post-surgery that progressively resolved by 6 months.