Key result
IP3R/Ca2+ channel modulation shows early therapeutic potential for neurodegenerative diseases.
Modulating IP3R activity represents a potential therapeutic target for neurodegenerative diseases, though current approaches remain in early preclinical stages.
Recent research into neurodegenerative disorders found that their pathogeneses have a link to the inositol 1,4,5-trisphosphate receptors (IP3R). This is encouraging, because despite extensive efforts, researchers have not fully understood the pathophysiologies of those disorders, and have yet to find the cure. The IP3R provides a possible point of convergence that new therapeutic drugs can target. This review highlights patents that manipulate activities of the IP3R. They generally involve the use of peptides designed from the amino acid sequences of IP3R-binding proteins, and of buffers that limit the availability of its ligand, IP3. Additionally, one of them details the use of a chromophore-conjugated small synthetic molecule to directly inhibit the IP3R in a highly spatiotemporally specific manner. Although many of them have only been tested in vitro or are in the early stages of in vivo application, more research-effective therapies for neurodegenerative diseases can hopefully be developed.
No takes yet. Share an insight, caveat, or question.
Carmen Chan (2013) conducted a review in Neurodegenerative disorders. Modulation of IP3R/Ca2+ channel was evaluated. Modulating the IP3R/Ca2+ channel using peptides, buffers, or synthetic molecules represents a potential therapeutic strategy for neurodegenerative diseases, though most remain in early testing.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: