What question did this study set out to answer?

To determine the physiological and clinical effects of oral mifepristone on second-trimester myometrial contractility and prostaglandin sensitivity.

June 1, 1990BJOG An International Journal of Obstetrics & Gynaecology

The physiological and clinical effects of progesterone inhibition with mifepristone (RU 486) in the second trimester

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Authors

NHN. C. W. HILLGreat Plains Tribal Chairmen’s Health Board MSM. SelingerRoyal Berkshire Hospital JFJane F. FergusonPreventive Cardiology

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Implication

Randomized double-blind trial demonstrates reduced abortion induction times with mifepristone in second-trimester primigravidae, indicating heightened myometrial sensitivity.

Key Points

To determine the physiological and clinical effects of oral mifepristone on second-trimester myometrial contractility and prostaglandin sensitivity.
Double-blind placebo-controlled trial of 20 primigravidae randomly assigned to oral mifepristone (600 mg, n=10) or placebo (n=10) 24 hours prior to abortion induction with extra-amniotic PGE2.
Spontaneous uterine activity and responsiveness to PGE2, ergometrine, and oxytocin were monitored using intrauterine pressure recordings, alongside maternal plasma PGE and PGF metabolite assays.
The mean induction-abortion interval was significantly shorter in the mifepristone group at 512 (SD 321) minutes versus 1128 (SD 606) minutes in the placebo group (P <= 0.02).
Mifepristone administration heightened spontaneous uterine activity and sensitivity to PGE2 and ergometrine without altering oxytocin responsiveness or peripheral plasma PGE and PGF metabolite concentrations.

Cite This Study

HILL et al. (1990) studied this question.

synapsesocial.com/papers/6aa7c003ac18924c76574546 https://doi.org/10.1111/j.1471-0528.1990.tb02517.x

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Implication

Randomized double-blind trial demonstrates reduced abortion induction times with mifepristone in second-trimester primigravidae, indicating heightened myometrial sensitivity.

The physiological and clinical effects of progesterone inhibition with mifepristone (RU 486) in the second trimester

Discussion

Member takes

Implication

Key Points

Cite This Study

The physiological and clinical effects of progesterone inhibition with mifepristone (RU 486) in the second trimester

Discussion

Member takes

Implication

Key Points

Cite This Study

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