Mifepristone followed by a prostaglandin analogue achieved a success rate of 95.3% in medical termination of early pregnancy among 15,709 women.
Does mifepristone followed by a prostaglandin analogue safely and effectively terminate early pregnancy in women?
Mifepristone followed by a prostaglandin analogue provides a highly effective and generally safe medical alternative to surgery for early pregnancy termination.
Absolute Event Rate: 0% vs 0%
We report the results of a large‐scale trial with mifepristonc (RU 486) followed by the administration of a prostaglandin (PG) analogue for the medical termination of early pregnancy. Altogether, 16,173 patients from 300 centers were evaluated. 48 women (0.3%) were lost to follow‐up prior to, and 416 (2.6%) after the PG administration, and therefore the efficacy was evaluated in 15,709 women. Overall. the success rate was 95.3%. with no statistical difference regarding the nature and dose of PG used. The median duration of bleeding was 8 days, being 12 days or less in 89.7% of the women. Bleeding was significant cnough to necessitate a vacuum aspiration or a dilatation and curettage in 0.8% of the cases. A blood transfusion was necessary in 0.1% of the women (11 patients). Serious cardio‐vascular side‐effects were reported in 4 cases after the PG (sulpro/tonc) injection: they consisted of one acute myocardial infarction attributed to a coronary spasm. and in marked hypotension in the other 3 woman. All patients recovered uneventfully. In conclusion, RU 486 followed by a PG analogue provides an efficient and safe medical alternative to surgery for early pregnancy termination, provided that the recommended protocol is adequately followed and the contraindications to prostaglandins are respected.
Ulmann et al. (Fri,) reported a other. Mifepristone followed by a prostaglandin analogue achieved a success rate of 95.3% in medical termination of early pregnancy among 15,709 women.