Key result
Amiodarone is linked to a ~0.4% allergic reaction rate in patients with iodine allergies.
Why the study?
Does amiodarone cause hypersensitivity reactions in hospitalized patients with a listed allergy to iodine or iodinated contrast agents?
Observational (n=234)
Yes
Does amiodarone cause hypersensitivity reactions in hospitalized patients with a listed allergy to iodine or iodinated contrast agents?
The incidence of amiodarone hypersensitivity in patients with a listed iodine or contrast allergy is less than 1%, suggesting these allergies may not be an absolute contraindication to amiodarone administration.
Answers are grounded in this paper and cite their sources.
Challenges absolute contraindication labeling for amiodarone in iodine-allergic patients; leaves open confirmation in prospective cohorts.
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Lakshmanadoss et al. (2012) conducted an observational in Allergy to iodine or iodinated contrast agents (n=234). Amiodarone was evaluated on Allergic reaction to amiodarone. Amiodarone administration in hospitalized patients with a listed allergy to iodine or iodinated contrast agents resulted in a probable allergic reaction in only 0.4% of patients.
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