Regional Coronary Endothelial Function Is Closely Related to Local Early Coronary Atherosclerosis in Patients With Mild Coronary Artery Disease
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Key result
Local coronary endothelial function correlates inversely with wall thickness in mild CAD but not healthy adults.
- r = -0.73
- P=0.0008
- n=28
Why the study?
Whether abnormal coronary endothelial function is related to noninvasive MRI measures of early atherosclerosis, such as increased coronary wall thickness, was unknown.
Does coronary endothelial function correlate with early anatomic atherosclerosis (coronary wall thickness) in patients with mild coronary artery disease?
Population
14 healthy adults and 14 patients with nonobstructive coronary artery disease
Comparison
Patients with nonobstructive coronary artery disease vs healthy adults
Design
Cross-sectional comparative study
Authors
Discussion
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Implication
May link endothelial dysfunction to early atherosclerosis in mild CAD; hypothesis-generating for combined MRI risk assessment.
Study Design
Type
Cross-Sectional (n=28)
Multicenter
No
Structured PICO
Does coronary endothelial function correlate with early anatomic atherosclerosis (coronary wall thickness) in patients with mild coronary artery disease?
P
Population
28 adults, comprising 14 healthy volunteers and 14 patients with mild, non-obstructive coronary artery disease, who underwent 3T MRI to assess coronary endothelial function and wall thickness.
E
Exposure
Coronary MRI before and during isometric handgrip exercise (endothelial-dependent stressor) and black blood imaging to quantify coronary wall thickness.
C
Comparator
Healthy adults
O
Outcome
Relationship between stress-induced changes in cross-sectional area (endothelial function) and coronary wall thickness.surrogate
Main Result
Effect estimate: r = -0.73
p-value: p=0.0008
Combined noninvasive MRI assessment reveals that local endothelial dysfunction is closely related to early anatomic atherosclerosis in patients with mild coronary artery disease.
Limitations
- Spatial resolution of MR imaging of the coronaries is not able to distinguish separate layers of the vessel wall or plaque components
- Limited in the choice of the coronary segment that can be imaged
- Relatively small sample size
- The healthy and CAD groups were not age-matched
Cite This Study
Hays et al. (2012) conducted a cross-sectional in Mild coronary artery disease (n=28). Mild coronary artery disease vs. Healthy adults was evaluated on Correlation between stress-induced change in coronary cross-sectional area and coronary wall thickness (r = -0.73, p=0.0008). In patients with mild coronary artery disease, local coronary endothelial function correlated inversely with coronary wall thickness (r = -0.73, p=0.0008), a relationship not observed in healthy adults.
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