Local coronary wall eccentricity and endothelial function are closely related in patients with atherosclerotic coronary artery disease
Why the study?
Is local coronary endothelial macrovascular function associated with the degree of local coronary wall eccentricity in patients with coronary artery disease?
Population
45 subjects (29 patients with known coronary artery disease and 16 healthy subjects)
Comparison
3 T coronary cardiovascular magnetic resonance… vs Healthy subjects (for group comparison)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Coronary eccentricity was associated with impaired endothelial function in CAD; hypothesis-generating for integrating anatomic and functional plaque markers.
Structured PICO
Is local coronary endothelial macrovascular function associated with the degree of local coronary wall eccentricity in patients with coronary artery disease?
P
Population
45 subjects (29 patients with known coronary artery disease and 16 healthy subjects)
I
Intervention
3 T coronary cardiovascular magnetic resonance (CMR) during isometric handgrip exercise (IHE) and black-blood MRI
C
Comparator
Healthy subjects (for group comparison)
O
Outcome
Relationship between stress-induced percent change in coronary cross-sectional area (%CSA) and coronary eccentricity index (EI)surrogate
Noninvasive CMR demonstrates a significant inverse relationship between coronary endothelial macrovascular function and local coronary wall eccentricity in CAD patients, linking anatomic and physiologic markers of high-risk plaque.
Cite This Study
Hays et al. (2016) studied this question.