Key result
Higher dietary salt intake linked to abnormal nocturnal blood pressure dipping, particularly in reverse dippers.
Why the study?
Is dietary salt intake associated with abnormal nocturnal blood pressure fall patterns in patients with essential hypertension?
Population
5,538 untreated patients with mild to moderate chronic uncomplicated essential hypertension, mean age…
Design
Cohort
Authors
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May inform salt assessment in non-dipping hypertension; hypothesis-generating for RCTs on whether restriction normalizes nocturnal patterns.
Observational (n=5,538)
Is dietary salt intake associated with abnormal nocturnal blood pressure fall patterns in patients with essential hypertension?
p-value: p=<0.00001
Increased dietary salt intake is significantly associated with abnormal nocturnal blood pressure fall patterns, particularly reverse dipping, in patients with essential hypertension.
Vyssoulis et al. (2005) conducted an observational in mild to moderate chronic uncomplicated essential hypertension (n=5,538). Dietary salt intake (measured by 24-hour urinary sodium excretion) vs. Normal nocturnal blood pressure fall patterns (dippers) was evaluated on 24-hour urine sodium concentration (Na24) and sodium to creatinine ratio across nocturnal blood pressure fall patterns (p=<0.00001). Increased dietary salt intake was significantly associated with abnormal nocturnal blood pressure fall patterns, with 24-hour sodium peaking at 138 mmol/l in reverse dippers (p<0.00001).
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