Key result
Voltage clamp analysis establishes sheep cardiac Purkinje tissue membrane capacitance at ~0.9 muF/cm2.
Population
Sheep cardiac Purkinje tissue
Design
Preclinical
Authors
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Provides quantitative Purkinje parameters for sheep models; leaves open translation to human electrophysiology.
This preclinical study provides quantitative estimates of membrane capacitance and slope conductance in sheep cardiac Purkinje fibers, highlighting the importance of modeling and structural analysis.
Hellam et al. (1974) studied Sheep cardiac Purkinje tissue. Constant current pulses, ramp commands, or small changes in holding potential was evaluated on Membrane capacitance and slope conductance. In sheep cardiac Purkinje tissue, the slope conductance of unit membrane area at -80 mV is 0.09 mmho/cm2, and the capacitance near -90 mV is 0.9 muF/cm2.
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