Key result
Chronic renal failure links nocturia to reversed circadian urine flow, not increased 24-hour volume.
Why the study?
Does chronic renal failure alter the circadian pattern of urine excretion compared to healthy controls?
Population
19 patients with stable chronic renal failure of varying severity and 18 healthy control subjects of similar…
Comparison
Observation of 24-hour urine excretion patterns vs 18 healthy control subjects
Design
Case-control
Follow-up
24 hours
Authors
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May guide nocturia evaluation in chronic renal failure; hypothesis-generating and should not yet change practice.
Case-Control (n=37)
Does chronic renal failure alter the circadian pattern of urine excretion compared to healthy controls?
Absolute Event Rate: 1608% vs 1710%
Nocturia in chronic renal failure is driven by a reversal of the normal circadian rhythm of urine flow rather than an absolute increase in 24-hour urine volume.
Hillier et al. (1980) conducted a case-control in Chronic Renal Failure (n=37). Chronic renal failure vs. Healthy control subjects was evaluated on 24 hour urine volume (ml). Patients with chronic renal failure exhibited nocturia due to a reversed circadian pattern of urine flow, rather than increased 24-hour urine volume (1608 vs 1710 ml in controls).
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