Key result
Surgery for acquired heart defects is linked to new diastolic dysfunction in ~27% of patients.
Why the study?
To assess dynamics of diastolic function to detect diastolic dysfunction and its causes, and evaluate its prognostic effect postoperatively in patients with acquired heart diseases.
Cohort (n=112)
Postoperative diastolic dysfunction after valve surgery is associated with septal diastolic function impairment and myocardial fibrosis, indicating inadequate myocardial protection.
May warrant septal velocity monitoring post-valve surgery; leaves open whether enhanced myocardial protection reduces diastolic dysfunction incidence.
OBJECTIVE: to assess dynamics of diastolic function for detection of development of diastolic dysfunction (DD) and it's causes, to evaluate the effect of DD on prognosis in the postoperative period in patients with acquired heart diseases. MATERIALS AND METHODS: We included in this study 112 patients with aortic and mitral valve diseases (90 men, 22 women, median age 51 [35; 57] years). All patients underwent echocardiography (echo), tissue Doppler, speckle tracking echo prior to surgery, in the early postoperative period (8-14 days) and in 12-36 months after surgery. In 28 patients dynamic contrast-enhanced magnetic resonance imaging was also performed. Patients were divided into groups according to prognosis: group 0 - without complications; group 1 - with postoperative heart failure (HF) and preserved left ventricular ejection fraction (EF); group 2 - with HF and EF <45 %. The following parameters were used for identifying left ventricular (LV) DD: septal velocity es <7 cm / sec, lateral el <10 cm / sec, average E / e ratio >14, left atrial (LA) volume index >34 ml / m2, peak tricuspid regurgitation velocity >2.8 m / sec. RESULTS: Initially diastolicLV function was normal in 34 of 112 patients (30.4 %), in early postoperative period DD emerged in 9 (26.5 %) of these patients. The appearance of LV DD was associated with decrease of septal es immediately after surgery and its subsequent progressive decline in the long-term postoperative period from 8.5±0.71 to 4.6 ±0.53 cm / sec (p=0.005). Worsening of diastolic function and lowering of septal velocity was detected namely in patients with presence of fibrosis. In the group of other patients in whom fibrosis was not studied and the degree of DD increased there was a transient decrease of lateral el (from 10.2±3.1 to 7.5±2.43 cm / sec, p=0.035) and an increase of the E / el (from 10.53±4.07 to 14.5±5.23, p=0.05) in the early period after the operation. There were no correlations between DD and LV EF,LV volumes, and development of arrhythmias. The prognostic model for DD included average longitudinal deformation of LA (global LA longitudinal strain) and E / e ratio on the tricuspid lateral annular velocity. CONCLUSIONS: Appearance of DD in postoperative period after correction of acquired heart defects was due to damage of the septal diastolic function which correlated with fibrosis and was indicative of inadequate myocardial protection. The model of development of heart failure with normal EF after operation was designed.
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Аверина et al. (2019) conducted a cohort in Aortic and mitral valve diseases (n=112). Valve surgery vs. Preoperative baseline was evaluated on Development of diastolic dysfunction in patients with initially normal diastolic function. Following surgery for acquired heart defects, diastolic dysfunction developed in 26.5% of patients with normal baseline function, associated with a progressive decline in septal velocity (p=0.005).
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