Key result
Integrative Chinese and Western medicine linked to ~27% lower MACE risk vs conventional medicine post-PCI.
Why the study?
Integrative Chinese and Western Medicine is widely used in CAD patients after PCI in China, but evidence from large samples on long-term prognosis remains weak.
Does Integrative Chinese and Western Medicine reduce the composite of all-cause death, revascularization, and myocardial infarction in patients after percutaneous coronary intervention?
Cohort (n=5,453)
No
Does Integrative Chinese and Western Medicine reduce the composite of all-cause death, revascularization, and myocardial infarction in patients after percutaneous coronary intervention?
Hazard Ratio: 0.73 (95% CI 0.63–0.85)
Absolute Event Rate: 11.54% vs 15.31%
p-value: p=<0.0001
Integrative Chinese and Western Medicine is associated with a lower risk of 2-year major adverse cardiovascular events compared to conventional western medicine alone in patients after PCI.
Should not yet change post-PCI regimens; hypothesis-generating for integrative approaches and requires randomized confirmation.
Background Integrative Chinese and Western Medicine (ICWM) is widely used in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) in China. However, the evidence-based on the long-term prognosis and large sample on this topic are weak. The purpose of this study is to evaluate the correlation between the therapeutic effect of ICWM and the prognosis of patients after PCI.Methods This study is a prospective observational real-world cohort study that was conducted from September 2016 to August 2019 in Fuwai Hospital. The study was reviewed and approved by the Ethics Review Committee of Fuwai Hospital, Chinese Academy of Medical Sciences. We consecutively screened 6000 patients after PCI and they were followed up for 2 years. ICWM were related to prognostic outcomes using unadjusted (Kaplan-Meier curves) and risk-adjusted (multivariable Cox regression) analyses. The primary endpoint was a composite of all-cause death, revascularization, and myocardial infarction.Results A total of 5942 patients after PCI were enrolled in this study, 5453 patients were included in the final analysis (4189[76.8%] were male; mean [SD] age, 61.91[9.91] years). There were 2932 patients (53.8%) in western medicine group (WMG) and 2521 patients (46.2%) in integrated medicine group (IMG). Cox regression analysis showed that IMG had a 27% lower cumulative risk of the major adverse cardiovascular event (MACE) than WMG (hazard ratio [HR], 0.73; 95% CI, 0.63-0.85; P＜0.0001), especially in all-cause mortality and revascularization.Conclusions Among patients after PCI, ICWM compared with conventional western medicine was correlated with a lower risk of 2-year MACE. Further research is needed to provide higher levels of evidence.
No takes yet. Share an insight, caveat, or question.
Yan et al. (2021) conducted a cohort in Coronary artery disease after percutaneous coronary intervention (n=5,453). Integrative Chinese and Western Medicine vs. Conventional western medicine was evaluated on Composite of all-cause death, revascularization, and myocardial infarction (MACE) (HR 0.73, 95% CI 0.63-0.85, p=<0.0001). Integrative Chinese and Western Medicine was associated with a 27% lower risk of major adverse cardiovascular events (HR 0.73) compared to conventional western medicine alone in patients after PCI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: