Key result
Bariatric surgery shifts adaptive immunity to reduce chronic inflammation and improve insulin sensitivity.
Why the study?
To examine the interplay between adaptive immune system changes and improved insulin sensitivity in response to bariatric surgery-induced weight loss.
Does bariatric surgery improve adaptive immune system profiles and insulin resistance in severe obesity?
Design
Review
Authors
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Bariatric surgery-associated immune shifts may reduce inflammation in obesity; leaves open whether prospective trials will confirm causality or guide practice.
Does bariatric surgery improve adaptive immune system profiles and insulin resistance in severe obesity?
Bariatric surgery induces a shift in the adaptive immune system from a proinflammatory to an anti-inflammatory phenotype, which may drive the reduction in low-grade chronic inflammation and improvement in insulin sensitivity.
Villarreal-Calderón et al. (2019) conducted a review in Obesity. Bariatric surgery was evaluated. Bariatric surgery induces a shift in adaptive immune cells from a proinflammatory to an anti-inflammatory phenotype, reducing low-grade chronic inflammation and improving insulin sensitivity.
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