Ex vivo study demonstrates beta-blocker antagonism of isoprenaline-mediated histamine inhibition in sensitized lung tissues, indicating beta-adrenoceptor involvement in antianaphylactic responses.
beta-Adrenoceptor blocking agents antagonized the inhibitory (antianaphylactic) effect of isoprenaline on antigen-induced histamine release in isolated, passively sensitized, human lung and actively sensitized guinea-pig lung suggesting that the effect is exerted through beta-adrenoceptors. No antagonism was obtained with the human allergic leucocyte preparation.2. The antianaphylactic effect of isoprenaline was antagonized not only by propranolol but also by the ;selective' beta-adrenoceptor blocking agents, practolol and butoxamine.3. The classification of beta-adrenoceptors is discussed. Certain similarities between antianaphylactic and lipolytic beta-adrenoceptors are noted.
No takes yet. Share an insight, caveat, or question.
Assem et al. (1971) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: