The modulatory effects of prostaglandins on both excitatory and inhibitory non‐adrenergic non‐choIinergic neurotransrnission in guinea‐pig airways

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Johansson‐Rydberg, I. G. M., Andersson, R. G. G. & Grundström, N. 1992, The modulatory effects of prostaglandins on both excitatory and inhibitory non‐adrenergic non‐cholinergic neurotransmission in guinea‐pig airways. Acta Physiol Scand144, 439444. Received 28 August 1991, accepted 20 November 1991. ISSN 0001–6772. Department of Pharmacology, University Hospital of Linkoping, Sweden. Guinea‐pig trachea and bronchi were used to investigate the effects of indomethacin and prostaglandin E2 (PGE2) on non‐adrenergic non‐cholinergic excitatory (e‐NANC) and inhibitory (i‐NANC) neurotransmission evoked by electrical field stimulation. Indomethacin potentiated e‐NANC responses in bronchi with intact epithelium but had no effect on epithelium‐denuded preparations. Inhibitory NANC responses were increased by indomethacin independent of the epithelium. Both i‐NANC and e‐NANC neurotransmission were suppressed by PGE2 in a dose‐dependent manner. These results indicate that endogenous prostaglandins (e.g. PGE2) generated from the epithelium have an inhibitory effect on i‐NANC and e‐NANC nerve responses in airways. The epithelium is presumably not the only source for generation of prostaglandins that are involved in i‐NANC neurotransmission.