Key result
Local bupivacaine nerve block fails to alter nocturnal hyperaemic blood flow increases versus unblocked control.
Why the study?
Does peripheral nervous blockade prevent nocturnal fluctuations in lower-leg subcutaneous blood flow in normal human subjects?
Does peripheral nervous blockade prevent nocturnal fluctuations in lower-leg subcutaneous blood flow in normal human subjects?
p-value: p=0.83
Peripheral nervous blockade does not affect nocturnal subcutaneous hyperaemia, suggesting central nervous factors are not the eliciting mechanism.
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Peripheral blockade does not blunt nocturnal hyperaemia; leaves open central mechanisms as primary driver in healthy subjects.
Sindrup et al. (1993) studied Healthy volunteers (n=10). Local nervous blockade (bupivacaine) vs. Left lower leg (unblocked control) was evaluated on Relative blood flow increase during the hyperaemic phase (p=0.83). Local nervous blockade with bupivacaine did not significantly affect the relative blood flow increase during the nocturnal hyperaemic phase compared to the unblocked control leg (P = 0.83).
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