Key result
Intrahepatic cholestasis of pregnancy links to higher serum betatrophin levels compared to healthy pregnancies.
Why the study?
The relationship between maternal serum betatrophin levels and total bile acid levels in intrahepatic cholestasis of pregnancy was not well understood.
Are maternal serum betatrophin levels elevated in intrahepatic cholestasis of pregnancy and do they correlate with total bile acid levels?
Case-Control (n=82)
Are maternal serum betatrophin levels elevated in intrahepatic cholestasis of pregnancy and do they correlate with total bile acid levels?
Betatrophin levels are elevated in intrahepatic cholestasis of pregnancy and correlate with total bile acid levels, suggesting a potential role in the disease's metabolic pathophysiology.
Elevated betatrophin in ICP may reflect metabolic dysregulation; hypothesis-generating for its role in bile acid pathophysiology and requires prospective validation.
Objective: To investigate maternal serum levels of betatrophin and their relationship with total bile acid (TBA) levels in patients with intrahepatic cholestasis of pregnancy (ICP).Materials and methods: Fifty-nine pregnant women with ICP (31 patients with severe and 28 patients with mild disease classifications) and 23 healthy women with uncomplicated pregnancies as the control group included the study. The maternal betatrophin, fasting blood glucose, fasting insulin (FI), and homeostatic model assessment of insulin resistance (HOMA-IR) levels of the groups were compared.Results: Serum betatrophin levels were significantly higher in the ICP groups than in the control group (p = .04 and p < .001, respectively). The FI levels and HOMA-IR values were significantly higher in the severe ICP group than in the control group (p = .006 and p = .001, respectively). While a significant positive correlation was found between betatrophin levels and fasting and postprandial TBA levels, there was no significant correlation among betatrophin and HOMA-IR or FI levels.Conclusions: Betatrophin levels were shown to correlate with TBA levels, it provides a model for future studies to understand the physiopathology of ICP, a complex metabolic disease. Changes in betatrophin levels may shed light on the pathogenesis of ICP.
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Kara et al. (2018) conducted a case-control in Intrahepatic cholestasis of pregnancy (n=82). Intrahepatic cholestasis of pregnancy vs. Healthy women with uncomplicated pregnancies was evaluated on Maternal serum betatrophin levels (p=0.04 and <0.001). Intrahepatic cholestasis of pregnancy was associated with significantly higher serum betatrophin levels compared to healthy uncomplicated pregnancies (p=0.04 and p<0.001 for mild and severe disease).
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