Key result
4-aminopyridine increases noradrenaline output ~fivefold by inactivating potassium current and prolonging the action potential.
4-aminopyridine enhances noradrenaline release from sympathetic nerves, likely by inactivating potassium currents and prolonging action potentials to increase calcium influx.
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Animal data on potassium channel effects in sympathetic nerves leave open translation to human cardiovascular physiology or therapy.
Kirpekar et al. (1977) studied this question. 4-aminopyridine vs. control was evaluated on release of noradrenaline from the perfused cat spleen by nerve stimulation. 4-aminopyridine (1 mM) increased noradrenaline output from the perfused cat spleen at 5 Hz by about fivefold, likely by inactivating potassium current and prolonging the action potential.
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