Why the study?
Predicting postoperative outcomes using conventional hemodynamic parameters and risk scores immediately after pediatric cardiac surgery is unreliable, whereas trends in serum lactate or clearance may offer better estimates.
Population
131 pediatric cardiac surgery patients
Comparison
Lactate levels and clearance in nonsurvivors vs survivors
Design
Observational study
Key result
High immediate postoperative serum lactate levels were significantly associated with mortality in pediatric cardiac surgery (median 6.14 in nonsurvivors vs 2.50 in survivors; P<=0.0001).
Authors
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May support lactate for postoperative risk stratification in pediatric cardiac surgery; leaves open whether targeted interventions improve outcomes.
Observational (n=131)
Mean Difference: 2.53 (95% CI 1.02–4.33)
Absolute Event Rate: 6.14% vs 2.5%
p-value: p=<=0.0001
Patel et al. (2022) conducted an observational in pediatric cardiac surgery (n=131). High serum lactate levels and poor lactate clearance vs. Low serum lactate levels and good lactate clearance was evaluated on Lactate level immediately postoperatively (T0) in nonsurvivors vs survivors (MD 2.53, 95% CI 1.02-4.33, p=<=0.0001). High immediate postoperative serum lactate levels were significantly associated with mortality in pediatric cardiac surgery (median 6.14 in nonsurvivors vs 2.50 in survivors; P<=0.0001).
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