Key result
Antitumor therapy can cause significant cardiovascular toxicity, including left ventricular dysfunction and heart failure, necessitating timely identification of baseline risk factors and regular monitoring.
Why the study?
Improved cancer survival has increased the clinical significance of antitumor treatment side effects, highlighting the need to identify cardiovascular toxicity and diagnose heart failure without inappropriately interrupting cancer therapy.
Timely identification of cardiovascular risk factors and diseases in cancer patients can improve prognosis and quality of life while avoiding inappropriate interruption of cancer therapy.
The field of cardio-oncology has received increasing attention in recent years. This is due to the fact that the results of a large number of clinical studies on antitumor therapy, covering issues treatments side effects, including associated cardiovascular pathology, are published. Advances in treatment have led to improved survival of patients with cancer, but have also increased clinical significance of treatment side effects. Myocardium, having high metabolic activity, responds to substrate and energy imbalance under the action of increasing malignancy and toxic effects of radio- or chemotherapy. Finding of baseline risk factors, timely identification of cardiovascular diseases, ability to predict the long-term consequences of cancer treatment-associated cardiovascular side effects lead to improving of the prognosis and quality of life, avoiding of over-diagnosis cardiovascular diseases and inappropriating violation of life-saving treatment of a malignant tumor.
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Obrezan et al. (2019) conducted a review in Cancer treatment-induced cardiovascular toxicity and heart failure. Antitumor therapy (chemotherapy, radiotherapy, targeted therapy) was evaluated. Antitumor therapy can cause significant cardiovascular toxicity, including left ventricular dysfunction and heart failure, necessitating timely identification of baseline risk factors and regular monitoring.
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