Key result
Overweight or obese BMI links to ~32% lower mortality after PCI, reflecting the obesity paradox.
Why the study?
Elevated BMI shows lower mortality in chronic diseases, prompting evaluation of the relationship between BMI and post-PCI outcomes in CAD patients, including sex-specific impacts.
Does elevated BMI improve clinical outcomes in CAD patients following PCI?
Population
CAD patients following PCI
Comparison
Lean vs normal-weight vs overweight/obese BMI categories
Authors
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Should not change post-PCI management; leaves open whether obesity paradox reflects confounding or warrants prospective confirmation.
Cohort
Does elevated BMI improve clinical outcomes in CAD patients following PCI?
Hazard Ratio: 0.68 (95% CI 0.48–0.95)
p-value: p=0.03
An obesity paradox is evident in CAD patients after PCI, with elevated BMI independently associated with reduced mortality in both males and females.
Morishita et al. (2022) conducted a cohort in Coronary artery disease (CAD) following percutaneous coronary intervention (PCI). Overweight/obese body mass index (BMI) vs. Normal-weight or lean BMI was evaluated on All-cause mortality (HR 0.68, 95% CI 0.48-0.95, p=0.03). Overweight/obese BMI was associated with a reduced risk of all-cause mortality after percutaneous coronary intervention (HR 0.68; 95% CI 0.48-0.95; p=0.03), demonstrating an obesity paradox.
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