Key result
Concentric LV hypertrophy and remodeling are linked to a ~64% steeper age-related GFR decline.
Why the study?
Does concentric left ventricular geometry correlate with an accelerated age-associated decline in renal function in patients with never-treated essential hypertension?
Population
840 subjects, comprising 195 normotensive subjects and 645 patients with never-treated essential hypertension.
Comparison
Concentric left ventricular geometry vs Eccentric hypertrophy, normal left ventricular…
Design
Cross-sectional
Authors
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Concentric LV geometry may flag faster GFR decline in untreated hypertension; cross-sectional data leave causal links and practice implications open.
Observational (n=840)
Does concentric left ventricular geometry correlate with an accelerated age-associated decline in renal function in patients with never-treated essential hypertension?
Absolute Event Rate: -0.95% vs -0.58%
p-value: p=< 0.01
In never-treated essential hypertension, a concentric pattern of left ventricular remodeling is associated with a more rapid age-related decline in glomerular filtration rate, independent of blood pressure levels.
Fesler et al. (2003) conducted an observational in Essential hypertension (n=840). Concentric left ventricular geometry (hypertrophy or remodeling) vs. Eccentric hypertrophy or normal left ventricular geometry was evaluated on Age-associated decline in GFR (slope of GFR versus age in ml/min per yr) (p=< 0.01). Concentric LV hypertrophy and remodeling were associated with a steeper age-related decline in GFR (-0.95 and -0.86 ml/min/yr) compared to normal LV geometry (-0.58 ml/min/yr; P<0.01).
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