Key result
Anlotinib treatment for hepatic angiosarcoma precedes fatal splenic rupture and bleeding at 2 months.
Why the study?
Hepatic angiosarcoma is a rare, aggressive tumor with high mortality, and this presents the first report of hepatic angiosarcoma accompanied by eosinophilia.
Case Report (n=1)
No
This is the first reported case of hepatic angiosarcoma accompanied by eosinophilia, highlighting a potential atypical clinical manifestation of this rare and highly fatal tumor.
Eosinophilia may flag primary hepatic angiosarcoma; this Level 5 case leaves open anlotinib's splenic rupture risk.
Background: Hepatic angiosarcoma is an extremely rare, uncontrollable tumor with strong invasion, high mortality rate, and extremely poor prognosis. There is first report on hepatic angiosarcoma accompanied by eosinophilia. Case Presentation: A woman with a chief complaint of poor appetite for about 3 months presented to a local hospital with a liver mass. Laboratory examination revealed a significant increase in eosinophils count was 9.58% in the serum. Abdominal MRI revealed multiple focal high-density lesions in the liver and spleen, and cranial MRI revealed multiple high-density shadows in the skull. Laparoscopic biopsy revealed a hepatic angiosarcoma and targeted treatment with Anlotinib was performed. Two months later, the patient died of splenic rupture and bleeding. Conclusion: Hepatic angiosarcoma often has no specific clinical manifestations, and we found that this case can lead to an increase in eosinophils, which is worth the attention of clinical physicians.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2025) conducted a case report in Hepatic angiosarcoma with eosinophilia (n=1). Anlotinib was evaluated on Clinical outcome. A 60-year-old woman with primary hepatic angiosarcoma and eosinophilia received targeted treatment with anlotinib but died of splenic rupture and bleeding two months later.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: